Immobilisation of organocatalysts onto solid supports represents a very promising solution to tackle their low productivity by enabling their reuse. Herein, the use of NMR relaxation measurements, coupled with reaction screening, was used to investigate the effect of solvent interactions with the immobilised catalyst matrix on reactivity in an asymmetric organocatalysed aldol reaction. Important insights for the further development of such complex, yet promising catalytic systems are provided. This journal is
NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline / Graziano Di Carmine, Luke Forster, Simeng Wang, Christopher Parlett, Armando Carlone, Carmine D'Agostino. - In: REACTION CHEMISTRY & ENGINEERING. - ISSN 2058-9883. - ELETTRONICO. - 7:2(2022), pp. 269-274. [10.1039/d1re00471a]
NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline
Carmine D'Agostino
2022
Abstract
Immobilisation of organocatalysts onto solid supports represents a very promising solution to tackle their low productivity by enabling their reuse. Herein, the use of NMR relaxation measurements, coupled with reaction screening, was used to investigate the effect of solvent interactions with the immobilised catalyst matrix on reactivity in an asymmetric organocatalysed aldol reaction. Important insights for the further development of such complex, yet promising catalytic systems are provided. This journal isI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
