Heterogeneous organocatalysts hold great potential as they offer practical advantages in terms of purification and reusability compared with the homogeneous counterpart. A puzzling aspect is the solvent effect on their catalytic performance. Here we propose a new approach whereby T1/T2 NMR relaxation measurements are used to evaluate the strength of solvent–surface interactions in the polystyrene-supported N-heterocyclic carbene-promoted oxidation of aldehydes. The results reveal that solvents with high surface affinity lead to a decrease in catalyst activity.
Di Carmine G, Ragno D, Massi A, D'Agostino C (2020). Oxidative coupling of aldehydes with alcohol for the synthesis of esters promoted by polystyrene-supported N-Heterocyclic Carbene: Unravelling the solvent effect on the catalyst behavior using NMR relaxation. ORGANIC LETTERS, 22, 4927-4931 [10.1021/acs.orglett.0c01188?ref=pdf].
Oxidative coupling of aldehydes with alcohol for the synthesis of esters promoted by polystyrene-supported N-Heterocyclic Carbene: Unravelling the solvent effect on the catalyst behavior using NMR relaxation
D'Agostino C
Ultimo
2020
Abstract
Heterogeneous organocatalysts hold great potential as they offer practical advantages in terms of purification and reusability compared with the homogeneous counterpart. A puzzling aspect is the solvent effect on their catalytic performance. Here we propose a new approach whereby T1/T2 NMR relaxation measurements are used to evaluate the strength of solvent–surface interactions in the polystyrene-supported N-heterocyclic carbene-promoted oxidation of aldehydes. The results reveal that solvents with high surface affinity lead to a decrease in catalyst activity.File | Dimensione | Formato | |
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Organic Letters, D'Agostino, 2020.pdf
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