A synthesis of pyrido[2,1-a]isoindoles is reported by the rhodium-catalyzed direct oxidative CH acylation of 2-aryl pyridines with terminal alkynes. The desired products were obtained in moderate to excellent yields. This is an efficient and clean method to construct C-C/C-N bonds in one step. In addition, the effective rhodium(III) catalyst was isolated and characterized by X-ray crystallography.
Zhao B., Yu M., Liu H., Chen Y., Yuan Y., Xie X. (2014). Rhodium-Catalyzed Direct Oxidative C-H Acylation of 2-Arylpyridines with Terminal Alkynes: A Synthesis of Pyrido[2,1-a]isoindoles. ADVANCED SYNTHESIS & CATALYSIS, 356(16), 3295-3301 [10.1002/adsc.201400198].
Rhodium-Catalyzed Direct Oxidative C-H Acylation of 2-Arylpyridines with Terminal Alkynes: A Synthesis of Pyrido[2,1-a]isoindoles
Zhao B.;
2014
Abstract
A synthesis of pyrido[2,1-a]isoindoles is reported by the rhodium-catalyzed direct oxidative CH acylation of 2-aryl pyridines with terminal alkynes. The desired products were obtained in moderate to excellent yields. This is an efficient and clean method to construct C-C/C-N bonds in one step. In addition, the effective rhodium(III) catalyst was isolated and characterized by X-ray crystallography.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
