A novel transformation for the construction of Csp3-Csp bonds was achieved via a photo-induced copper-catalysed C-C bond cleavage. This approach was applied to prepare a series of highly functionalized alkynyl nitriles using readily available cyclobutanones and terminal alkynes. Mechanistic exploration showed that the in situ generated copper acetylide complex is an effective photosensitive catalyst to promote the C-C bond cleavage of cycloketoxime esters through a radical process.
Zhao B., Wu Y., Yuan Y., Shi Z. (2020). Copper-catalysed Csp3-Csp cross-couplings between cyclobutanone oxime esters and terminal alkynes induced by visible light. CHEMICAL COMMUNICATIONS, 56(34), 4676-4679 [10.1039/d0cc00988a].
Copper-catalysed Csp3-Csp cross-couplings between cyclobutanone oxime esters and terminal alkynes induced by visible light
Zhao B.
;
2020
Abstract
A novel transformation for the construction of Csp3-Csp bonds was achieved via a photo-induced copper-catalysed C-C bond cleavage. This approach was applied to prepare a series of highly functionalized alkynyl nitriles using readily available cyclobutanones and terminal alkynes. Mechanistic exploration showed that the in situ generated copper acetylide complex is an effective photosensitive catalyst to promote the C-C bond cleavage of cycloketoxime esters through a radical process.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
