Sterically bulky amino magnesium methyl complex, LMgCH3(THF)2 (L=NAr(SiMe3), Ar=4,2,6-Me(CHPh2)2-C6H2) has been employed as an efficient precatalyst for the deoxygenate hydroboration of a variety of aromatic and aliphatic acids with pinacolborane (HBpin) under mild reaction condition. Additionally, chemoselective hydroboration of carboxylic acids over esters was also achieved under the standard conditions. Two plausible reaction mechanisms were proposed based on the density functional theory (DFT) calculations and stoichiometric reactions.
Zheng Y., Cao X., Li J., Hua H., Yao W., Zhao B., et al. (2020). Efficient Magnesium-Catalyzed Hydroboration of Carboxylic Acids. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 40(7), 2086-2093 [10.6023/cjoc202003058].
Efficient Magnesium-Catalyzed Hydroboration of Carboxylic Acids
Zhao B.
;
2020
Abstract
Sterically bulky amino magnesium methyl complex, LMgCH3(THF)2 (L=NAr(SiMe3), Ar=4,2,6-Me(CHPh2)2-C6H2) has been employed as an efficient precatalyst for the deoxygenate hydroboration of a variety of aromatic and aliphatic acids with pinacolborane (HBpin) under mild reaction condition. Additionally, chemoselective hydroboration of carboxylic acids over esters was also achieved under the standard conditions. Two plausible reaction mechanisms were proposed based on the density functional theory (DFT) calculations and stoichiometric reactions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
