We describe an efficient catalyst- and metal-free aminoboration of alkynes to 3-borylated indoles using one of the least expensive boron sources, BCl3. The major dichloro(indolyl)borane products can be used for the in situ construction of useful 3-Bpin indoles. This simple and mild method provides a novel and efficient approach for the synthesis of various 3-borylated indoles with high regioselectivity and a wide substrate scope. (Figure presented.).
Lv J., Zhao B., Liu L., Han Y., Yuan Y., Shi Z. (2018). Boron Trichloride-Mediated Synthesis of Indoles via the Aminoboration of Alkynes. ADVANCED SYNTHESIS & CATALYSIS, 360(21), 4054-4059 [10.1002/adsc.201800509].
Boron Trichloride-Mediated Synthesis of Indoles via the Aminoboration of Alkynes
Zhao B.;Han Y.
;Shi Z.
2018
Abstract
We describe an efficient catalyst- and metal-free aminoboration of alkynes to 3-borylated indoles using one of the least expensive boron sources, BCl3. The major dichloro(indolyl)borane products can be used for the in situ construction of useful 3-Bpin indoles. This simple and mild method provides a novel and efficient approach for the synthesis of various 3-borylated indoles with high regioselectivity and a wide substrate scope. (Figure presented.).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
