It is attractive to establish an efficient and practical platform affording functional compounds using readily available feedstocks as starting materials under mild conditions. We describe a direct copper-catalyzed fluorocarboalkynylation of the readily available alkynes with excellent regio- and stereoselectivity. A wide range of conjugated trifluoromethyl 1,3-enynes were obtained in good yields by this operationally simple strategy. The mechanistic experiments and DFT calculation revealed that a radical-mediated process was involved in the catalytic cycle. This journal is
Zhao B., Zheng Y., Zhu T., Wang M., Wang M., Ma M. (2021). Copper-catalyzed regio- And stereoselective fluorocarboalkynylation of alkynes. ORGANIC CHEMISTRY FRONTIERS, 8(24), 6857-6862 [10.1039/d1qo01201k].
Copper-catalyzed regio- And stereoselective fluorocarboalkynylation of alkynes
Zhao B.
;Zheng Y.;
2021
Abstract
It is attractive to establish an efficient and practical platform affording functional compounds using readily available feedstocks as starting materials under mild conditions. We describe a direct copper-catalyzed fluorocarboalkynylation of the readily available alkynes with excellent regio- and stereoselectivity. A wide range of conjugated trifluoromethyl 1,3-enynes were obtained in good yields by this operationally simple strategy. The mechanistic experiments and DFT calculation revealed that a radical-mediated process was involved in the catalytic cycle. This journal isI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
