In the myocardial cell, stimulation of the K opioid receptor is involved in the modulation of cytosolic calcium and pH homeostasis, as well as in the regulation of myofilament responsiveness to calcium. In the present study, we found that prodynorphin mRNA, which encodes for the synthesis of a common precursor of opioid peptides interacting with K sites, is synthesized both in atrial and ventricular tissue of the rat heart. In adult cultured rat ventricular cardiomyocytes, the level of prodynorphin mRNA did not differ from that detected in the original ventricular tissue. This finding indicates that the myocardial cell is a source for prodynorphin gene expression and has the potential for an intrinsic synthesis of dynorphin-related peptides.

Ventura C., Canossa M., Vaona I., Carboni L., Caldarera C.M., Spampinato S., et al. (1993). Prodynorphin mRNA is synthesized in adult cultured rat ventricular cardiomyocytes. CARDIOSCIENCE, 4(1), 21-24.

Prodynorphin mRNA is synthesized in adult cultured rat ventricular cardiomyocytes

Ventura C.;Canossa M.;Vaona I.;Carboni L.;Caldarera C. M.;Spampinato S.;Guarnieri C.
1993

Abstract

In the myocardial cell, stimulation of the K opioid receptor is involved in the modulation of cytosolic calcium and pH homeostasis, as well as in the regulation of myofilament responsiveness to calcium. In the present study, we found that prodynorphin mRNA, which encodes for the synthesis of a common precursor of opioid peptides interacting with K sites, is synthesized both in atrial and ventricular tissue of the rat heart. In adult cultured rat ventricular cardiomyocytes, the level of prodynorphin mRNA did not differ from that detected in the original ventricular tissue. This finding indicates that the myocardial cell is a source for prodynorphin gene expression and has the potential for an intrinsic synthesis of dynorphin-related peptides.
1993
Ventura C., Canossa M., Vaona I., Carboni L., Caldarera C.M., Spampinato S., et al. (1993). Prodynorphin mRNA is synthesized in adult cultured rat ventricular cardiomyocytes. CARDIOSCIENCE, 4(1), 21-24.
Ventura C.; Canossa M.; Vaona I.; Carboni L.; Caldarera C.M.; Spampinato S.; Guarnieri C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/913225
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