The synthesis and the pharmacological evaluation at M2 and M3 muscarinic receptor subtypes of some analogs of diphenidol with a modified intermediate chain is reported. The butyl chain was rendered more rigid or more polar. All the new derivatives were tested both as hydrochlorides and as methiodides and one of them showed an interesting pharmacological profile in terms of activity and selectivity.
Varoli L., Burnelli S., Budriesi R., Guarnieri A., Chiarini A., Recanatini M. (1996). Synthesis and biological profile at muscarinic M2 and M3 receptor subtypes of some analogs of diphenidol. MEDICINAL CHEMISTRY RESEARCH, 6(9), 571-580.
Synthesis and biological profile at muscarinic M2 and M3 receptor subtypes of some analogs of diphenidol
Varoli L.;Burnelli S.;Budriesi R.;Guarnieri A.;Chiarini A.;Recanatini M.
1996
Abstract
The synthesis and the pharmacological evaluation at M2 and M3 muscarinic receptor subtypes of some analogs of diphenidol with a modified intermediate chain is reported. The butyl chain was rendered more rigid or more polar. All the new derivatives were tested both as hydrochlorides and as methiodides and one of them showed an interesting pharmacological profile in terms of activity and selectivity.File in questo prodotto:
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