A series of furazanyl- and furoxanyl-1,4-dihydropyridines has been synthesized and tested for their cardiovascular activity. The new compounds showed a modest activity in comparison with nifedipine and some selectivity for the myocardial muscle. The most active compound was diethyl 1,4-dihydro-2,6-dimethyl-4-(3-phenyl-4-furoxanyl)3,5-pyridine dicarboxylate, 4d.

Gasco A.M., Fruttero R., Sorba G., Gasco A., Budriesi R., Chiarini A. (1992). Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues. ARZNEIMITTEL-FORSCHUNG, 42(7), 921-925.

Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues

Budriesi R.;Chiarini A.
1992

Abstract

A series of furazanyl- and furoxanyl-1,4-dihydropyridines has been synthesized and tested for their cardiovascular activity. The new compounds showed a modest activity in comparison with nifedipine and some selectivity for the myocardial muscle. The most active compound was diethyl 1,4-dihydro-2,6-dimethyl-4-(3-phenyl-4-furoxanyl)3,5-pyridine dicarboxylate, 4d.
1992
Gasco A.M., Fruttero R., Sorba G., Gasco A., Budriesi R., Chiarini A. (1992). Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues. ARZNEIMITTEL-FORSCHUNG, 42(7), 921-925.
Gasco A.M.; Fruttero R.; Sorba G.; Gasco A.; Budriesi R.; Chiarini A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/911639
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