A series of furazanyl- and furoxanyl-1,4-dihydropyridines has been synthesized and tested for their cardiovascular activity. The new compounds showed a modest activity in comparison with nifedipine and some selectivity for the myocardial muscle. The most active compound was diethyl 1,4-dihydro-2,6-dimethyl-4-(3-phenyl-4-furoxanyl)3,5-pyridine dicarboxylate, 4d.
Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues / Gasco A.M.; Fruttero R.; Sorba G.; Gasco A.; Budriesi R.; Chiarini A.. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - STAMPA. - 42:7(1992), pp. 921-925.
Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues
Budriesi R.;Chiarini A.
1992
Abstract
A series of furazanyl- and furoxanyl-1,4-dihydropyridines has been synthesized and tested for their cardiovascular activity. The new compounds showed a modest activity in comparison with nifedipine and some selectivity for the myocardial muscle. The most active compound was diethyl 1,4-dihydro-2,6-dimethyl-4-(3-phenyl-4-furoxanyl)3,5-pyridine dicarboxylate, 4d.File in questo prodotto:
Eventuali allegati, non sono esposti
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
