Aim: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. Methods: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC. Results: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I 2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I 2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. Conclusion: The NLR ratio is a variable correlated to prognosis in RCC patients.
Nunno V.D., Mollica V., Gatto L., Santoni M., Cosmai L., Porta C., et al. (2019). Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: A systematic review and meta-analysis. IMMUNOTHERAPY, 11(7), 631-643 [10.2217/imt-2018-0175].
Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: A systematic review and meta-analysis
Mollica V.;Massari F.
2019
Abstract
Aim: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. Methods: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC. Results: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I 2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I 2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. Conclusion: The NLR ratio is a variable correlated to prognosis in RCC patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
