Until now only planar projections of the molecular shape of supercoiled circular DNA molecules could be imaged with scanning force microscopy (SFM). In the three‐dimensional image of a supercoiled pBR322 DNA molecule in this report, the chirality and writhing number can be “read” directly. Local changes in the supercoiling in individual DNA molecules can be monitored, which should be important for our understanding of biological processes such as DNA transcription. Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

Bruno Samorì*, C.N. (1993). DNA Supercoiling Imaged in Three Dimensions by Scanning Force Microscopy. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION IN ENGLISH, 32(10), 1461-1463 [10.1002/anie.199314611].

DNA Supercoiling Imaged in Three Dimensions by Scanning Force Microscopy

Giampaolo Zuccheri
Penultimo
Investigation
;
1993

Abstract

Until now only planar projections of the molecular shape of supercoiled circular DNA molecules could be imaged with scanning force microscopy (SFM). In the three‐dimensional image of a supercoiled pBR322 DNA molecule in this report, the chirality and writhing number can be “read” directly. Local changes in the supercoiling in individual DNA molecules can be monitored, which should be important for our understanding of biological processes such as DNA transcription. Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany
1993
Bruno Samorì*, C.N. (1993). DNA Supercoiling Imaged in Three Dimensions by Scanning Force Microscopy. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION IN ENGLISH, 32(10), 1461-1463 [10.1002/anie.199314611].
Bruno Samorì*, Carmelo Nigro, Valerio Armentario, Salvatore Cimieri, Giampaolo Zuccheri, Carla Quagliariello
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/906692
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 17
social impact