Until now detection and numeration of circulating tumor cells (CTCs) were essentially used as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it seems necessary to improve analytical methods related to isolation and characterization of CTCs. Discrepancies between published results corroborates this requirement. In this review we suggest a combination of markers able to reach the goal. Moreover to improve the clinical utility of CTC analysis, particularly in the therapeutic follow up of the disease, epithelial mesenchymal transition (EMT) level of a global CTC population should be studied.

Barriere G., Fici P., Gallerani G., Fabbri F., Zoli W., Rigaud M. (2014). Circulating tumor cells and epithelial, mesenchymal and stemness markers: Characterization of cell subpopulations. ANNALS OF TRANSLATIONAL MEDICINE, 2(11), 109-116 [10.3978/j.issn.2305-5839.2014.10.04].

Circulating tumor cells and epithelial, mesenchymal and stemness markers: Characterization of cell subpopulations

Fici P.;Gallerani G.;
2014

Abstract

Until now detection and numeration of circulating tumor cells (CTCs) were essentially used as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it seems necessary to improve analytical methods related to isolation and characterization of CTCs. Discrepancies between published results corroborates this requirement. In this review we suggest a combination of markers able to reach the goal. Moreover to improve the clinical utility of CTC analysis, particularly in the therapeutic follow up of the disease, epithelial mesenchymal transition (EMT) level of a global CTC population should be studied.
2014
Barriere G., Fici P., Gallerani G., Fabbri F., Zoli W., Rigaud M. (2014). Circulating tumor cells and epithelial, mesenchymal and stemness markers: Characterization of cell subpopulations. ANNALS OF TRANSLATIONAL MEDICINE, 2(11), 109-116 [10.3978/j.issn.2305-5839.2014.10.04].
Barriere G.; Fici P.; Gallerani G.; Fabbri F.; Zoli W.; Rigaud M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/906440
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