Omega-3 fatty acid and antioxidant enriched liposomes for nasal administration of anti-Alzheimer drugs

The purpose of this work was the formulation of liposomes for nasal administration of tacrine·HCl. This route has many advantages, in fact it is possible to convey the drug directly to the CNS, through the olfactory bulb. Part of tacrine administered can also be absorbed into the systemic circulation avoiding hepatic first pass effect. Liposomes were formulated with ingredients that have a beneficial effect against the disease. In particular, the cholesterol was replaced with α-tocopherol, and phospholipids were enriched with polyunsaturated fatty acids (DHA, EPA α-linolenic acid). This formulative approach allowed us to obtain 100% active liposomes against symptoms of Alzheimer's disease.