Canine adenovirus type 1 (CAdV‐1) is the causative agent of a systemic and potentially fatal viral disease of domestic and wild canids. In Italy, CAdV‐1 infection has also been occasionally described in dogs, but information on the epidemiology and its genomic features is still limited. A study was conducted on 291 dogs suspected of infectious gastrointestinal disease. Samples collected from dogs in southern Italy between 2017 and 2020 were analyzed. Virological and histopathological assays were carried out. The presence of CAdVs and other canine viral enteropathogens was investigated, and sequence and phylogenetic analyses were performed. CAdV‐1 was detected in six (2.1%) dead stray dogs alone or in mixed infections with other viruses. Gross lesions and histopathological findings referred to CAdV infection were observed, also involving the central nervous system tissues. All inoculated samples were successfully isolated. Sequence analysis evidenced divergences with the circulating strains previously described in Italy and a closer relation with older CAdV‐1 strains collected from other countries, suggesting a genetic heterogeneity of CAdV‐1 in Italy. The evidence of the circulation of CAdV‐1 and its genomic features allows us to have more in‐depth knowledge of the epidemiology and evolution of the CAdV‐1 genomic variants.

Study on the canine adenovirus type 1 (CAdV‐1) infection in domestic dogs in Southern Italy / Mira F, Puleio R, Schirò G, Condorelli L, Di Bella S, Chiaramonte G, Purpari G, Cannella V, Balboni A, Randazzo V, Antoci F, Vicari D, Guercio A. - In: PATHOGENS. - ISSN 2076-0817. - ELETTRONICO. - 11:11(2022), pp. 1254.1-1254.17. [10.3390/pathogens11111254]

Study on the canine adenovirus type 1 (CAdV‐1) infection in domestic dogs in Southern Italy

Balboni A;
2022

Abstract

Canine adenovirus type 1 (CAdV‐1) is the causative agent of a systemic and potentially fatal viral disease of domestic and wild canids. In Italy, CAdV‐1 infection has also been occasionally described in dogs, but information on the epidemiology and its genomic features is still limited. A study was conducted on 291 dogs suspected of infectious gastrointestinal disease. Samples collected from dogs in southern Italy between 2017 and 2020 were analyzed. Virological and histopathological assays were carried out. The presence of CAdVs and other canine viral enteropathogens was investigated, and sequence and phylogenetic analyses were performed. CAdV‐1 was detected in six (2.1%) dead stray dogs alone or in mixed infections with other viruses. Gross lesions and histopathological findings referred to CAdV infection were observed, also involving the central nervous system tissues. All inoculated samples were successfully isolated. Sequence analysis evidenced divergences with the circulating strains previously described in Italy and a closer relation with older CAdV‐1 strains collected from other countries, suggesting a genetic heterogeneity of CAdV‐1 in Italy. The evidence of the circulation of CAdV‐1 and its genomic features allows us to have more in‐depth knowledge of the epidemiology and evolution of the CAdV‐1 genomic variants.
2022
Study on the canine adenovirus type 1 (CAdV‐1) infection in domestic dogs in Southern Italy / Mira F, Puleio R, Schirò G, Condorelli L, Di Bella S, Chiaramonte G, Purpari G, Cannella V, Balboni A, Randazzo V, Antoci F, Vicari D, Guercio A. - In: PATHOGENS. - ISSN 2076-0817. - ELETTRONICO. - 11:11(2022), pp. 1254.1-1254.17. [10.3390/pathogens11111254]
Mira F, Puleio R, Schirò G, Condorelli L, Di Bella S, Chiaramonte G, Purpari G, Cannella V, Balboni A, Randazzo V, Antoci F, Vicari D, Guercio A
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/905332
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 7
  • ???jsp.display-item.citation.isi??? ND
social impact