Guinea-pig kidney contains β-4-N-acetylgalactosaminyltransferase which may be involved in the biosynthesis of the Sd a determinant expressed on Tamm-Horsfall glycoprotein. In the present study we show that this enzyme is expressed far more in the medulla than in the cortex of the kidney and that, among the other organs tested, is expressed only in colon and caecum. This transferase is ontogenically regulated, in that its activity is low at birth and increases as a function of age. From several aspects, the tissue distribution and the ontogenic expression of β-4-N-acetylgalactosaminyl-transferase and Tamm-Horsfall glycoprotein are similar. © 1987 Plenum Publishing Corporation.
Dall'Olio F., Malagolini N., Serafini F. (1987). Tissue distribution and age-dependent expression of β-4-N-acetylgalactosaminyltransferase in guinea-pig. BIOSCIENCE REPORTS, 7(12), 925-932 [10.1007/BF01122125].
Tissue distribution and age-dependent expression of β-4-N-acetylgalactosaminyltransferase in guinea-pig
Dall'Olio F.;Malagolini N.;Serafini F.
1987
Abstract
Guinea-pig kidney contains β-4-N-acetylgalactosaminyltransferase which may be involved in the biosynthesis of the Sd a determinant expressed on Tamm-Horsfall glycoprotein. In the present study we show that this enzyme is expressed far more in the medulla than in the cortex of the kidney and that, among the other organs tested, is expressed only in colon and caecum. This transferase is ontogenically regulated, in that its activity is low at birth and increases as a function of age. From several aspects, the tissue distribution and the ontogenic expression of β-4-N-acetylgalactosaminyl-transferase and Tamm-Horsfall glycoprotein are similar. © 1987 Plenum Publishing Corporation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.