Remote control: The title reaction facilitates the synthesis of complex chiral molecules while selectively forging multiple stereocenters at distant positions, namely five and six bond lengths away from the catalyst chiral fragment (see scheme; Boc=tert-butoxycarbonyl). The potential of the strategy is demonstrated through the one-step preparation of spirocyclopentane oxindoles having four contiguous stereocenters. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Tian X., Melchiorre P. (2013). Control of remote stereochemistry in the synthesis of spirocyclic oxindoles: Vinylogous organocascade catalysis. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 52(20), 5360-5363 [10.1002/anie.201301017].
Control of remote stereochemistry in the synthesis of spirocyclic oxindoles: Vinylogous organocascade catalysis
Melchiorre P.
Ultimo
Supervision
2013
Abstract
Remote control: The title reaction facilitates the synthesis of complex chiral molecules while selectively forging multiple stereocenters at distant positions, namely five and six bond lengths away from the catalyst chiral fragment (see scheme; Boc=tert-butoxycarbonyl). The potential of the strategy is demonstrated through the one-step preparation of spirocyclopentane oxindoles having four contiguous stereocenters. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
