Oligodendroglioma is genetically defined by concomitant IDH (IDH1/IDH2) mutation and whole-arm 1p/19q codeletion. Codeletion of 1p/19q traditionally evaluated by fluorescence in situ hybridization (FISH) cannot distinguish partial from whole-arm 1p/19q codeletion. Partial 1p/19q codeletion called positive by FISH is diagnostically a "false-positive" result. Chromosomal microarray (CMA) discriminates partial from whole-arm 1p/19q codeletion. Herein, we aimed to estimate the frequency of partial 1p/19q codeletion that would lead to a false-positive FISH result.
Ball, M.K., Kollmeyer, T.M., Praska, C.E., McKenna, M.L., Giannini, C., Raghunathan, A., et al. (2020). Frequency of false-positive FISH 1p/19q codeletion in adult diffuse astrocytic gliomas. NEURO-ONCOLOGY ADVANCES, 2(1), 1-9 [10.1093/noajnl/vdaa109].
Frequency of false-positive FISH 1p/19q codeletion in adult diffuse astrocytic gliomas
Giannini, Caterina;
2020
Abstract
Oligodendroglioma is genetically defined by concomitant IDH (IDH1/IDH2) mutation and whole-arm 1p/19q codeletion. Codeletion of 1p/19q traditionally evaluated by fluorescence in situ hybridization (FISH) cannot distinguish partial from whole-arm 1p/19q codeletion. Partial 1p/19q codeletion called positive by FISH is diagnostically a "false-positive" result. Chromosomal microarray (CMA) discriminates partial from whole-arm 1p/19q codeletion. Herein, we aimed to estimate the frequency of partial 1p/19q codeletion that would lead to a false-positive FISH result.| File | Dimensione | Formato | |
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Ball-vdaa109.pdf
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vdaa109_suppl_supplementary_materials.docx
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