Oligodendroglioma is genetically defined by concomitant IDH (IDH1/IDH2) mutation and whole-arm 1p/19q codeletion. Codeletion of 1p/19q traditionally evaluated by fluorescence in situ hybridization (FISH) cannot distinguish partial from whole-arm 1p/19q codeletion. Partial 1p/19q codeletion called positive by FISH is diagnostically a "false-positive" result. Chromosomal microarray (CMA) discriminates partial from whole-arm 1p/19q codeletion. Herein, we aimed to estimate the frequency of partial 1p/19q codeletion that would lead to a false-positive FISH result.
Frequency of false-positive FISH 1p/19q codeletion in adult diffuse astrocytic gliomas / Ball, Matthew K; Kollmeyer, Thomas M; Praska, Corinne E; McKenna, Michelle L; Giannini, Caterina; Raghunathan, Aditya; Jentoft, Mark E; Lachance, Daniel H; Kipp, Benjamin R; Jenkins, Robert B; Ida, Cristiane M. - In: NEURO-ONCOLOGY ADVANCES. - ISSN 2632-2498. - ELETTRONICO. - 2:1(2020), pp. vdaa109.1-vdaa109.9. [10.1093/noajnl/vdaa109]
Frequency of false-positive FISH 1p/19q codeletion in adult diffuse astrocytic gliomas
Giannini, Caterina;
2020
Abstract
Oligodendroglioma is genetically defined by concomitant IDH (IDH1/IDH2) mutation and whole-arm 1p/19q codeletion. Codeletion of 1p/19q traditionally evaluated by fluorescence in situ hybridization (FISH) cannot distinguish partial from whole-arm 1p/19q codeletion. Partial 1p/19q codeletion called positive by FISH is diagnostically a "false-positive" result. Chromosomal microarray (CMA) discriminates partial from whole-arm 1p/19q codeletion. Herein, we aimed to estimate the frequency of partial 1p/19q codeletion that would lead to a false-positive FISH result.| File | Dimensione | Formato | |
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