FGFR3-TACC3 (F3T3) fusions are seen in 3.1–11.7% of glioblastoma (GBM) cases with better survival [1, 4, 5, 7–9]. We endeavored to characterize methylation profles in detail, using a cohort of 79 F3T3-positive GBMs from 71 patients (seven patients with primary and recurrent tumor resections, Table S1). Compared to gliomas without a docu mented fusion, dimensionality reduction showed that F3T3- positive GBMs nested predominantly to GBM-mesenchymal and RTK-II subclasses (Fig. 1a). Transcriptomic analysis on 9 F3T3-positive and 31 negative patients (Fig. 1b) confrmed a previous fnding of activated mitochondrial activity and altered vascular activity [2, 6].

DNA methylation analysis of glioblastomas harboring FGFR3-TACC3 fusions identifies a methylation subclass with better patient survival

Giannini, Caterina;
2022

Abstract

FGFR3-TACC3 (F3T3) fusions are seen in 3.1–11.7% of glioblastoma (GBM) cases with better survival [1, 4, 5, 7–9]. We endeavored to characterize methylation profles in detail, using a cohort of 79 F3T3-positive GBMs from 71 patients (seven patients with primary and recurrent tumor resections, Table S1). Compared to gliomas without a docu mented fusion, dimensionality reduction showed that F3T3- positive GBMs nested predominantly to GBM-mesenchymal and RTK-II subclasses (Fig. 1a). Transcriptomic analysis on 9 F3T3-positive and 31 negative patients (Fig. 1b) confrmed a previous fnding of activated mitochondrial activity and altered vascular activity [2, 6].
Wu, Zhichao; Lopes Abath Neto, Osorio; Bale, Tejus A; Benhamida, Jamal; Mata, Douglas; Turakulov, Rust; Abdullaev, Zied; Marker, Daniel; Ketchum, Courtney; Chung, Hye-Jung; Giannini, Caterina; Quezado, Martha; Pratt, Drew; Aldape, Kenneth
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/901889
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