Liquid chromatography-tandem mass spectrometry (LC-MS/MS) panels that include glucocorticoid-related steroids are increasingly used to characterize and diagnose adrenal cortical diseases. Limited information is currently available about reproducibility of these measurements among laboratories. The aim of the study was to compare LC-MS/MS measurements of corticosterone, 11-deoxycortisol and cortisone at eight European centers and assess the performance after unification of calibration.
Fanelli, F., Bruce, S., Cantù, M., Temchenko, A., Mezzullo, M., Lindner, J.M., et al. (2022). Report from the HarmoSter study: inter-laboratory comparison of LC-MS/MS measurements of corticosterone, 11-deoxycortisol and cortisone. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 0(0), Online ahead of print-Online ahead of print [10.1515/cclm-2022-0242].
Report from the HarmoSter study: inter-laboratory comparison of LC-MS/MS measurements of corticosterone, 11-deoxycortisol and cortisone
Fanelli, Flaminia;Temchenko, Anastasia;Mezzullo, Marco;Nardi, Elena;Pagotto, Uberto
2022
Abstract
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) panels that include glucocorticoid-related steroids are increasingly used to characterize and diagnose adrenal cortical diseases. Limited information is currently available about reproducibility of these measurements among laboratories. The aim of the study was to compare LC-MS/MS measurements of corticosterone, 11-deoxycortisol and cortisone at eight European centers and assess the performance after unification of calibration.| File | Dimensione | Formato | |
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