The Panel also noted that, although the safety of zinc itself, in terms of amounts that may be consumed, is outside the remit of this Panel, at the 97.5th percentile the dietary zinc intake from total food only is already close to the UL, as established by the SCF. Based on the available, albeit limited toxicological database, the Panel concluded that at the anticipated use and use levels of zinc picolinate and zinc picolinate dihydrate, as a source of zinc, when added for nutritional purposes in food supplements, are not of safety concern as The Panel also concluded that the use of chromium (III) picolinate, as a source of chromium, is of no safety concern provided that the amount of supplemental chromium does not exceed the level of 250 μg/day, the value set by the World Health Organization. The Panel notes that recent reviews and evaluations of chromium (III) point at conflicting outcomes of genotoxicity assays and report diverging views and conclusions on the consequences of this genotoxicity issue for the ultimate safety assessment of chromium (III). The Panel is aware that given this situation, the safety of chromium (III) might need to be reevaluated in light of these recent reviews and evaluations.
Chromium picolinate, zinc picolinate and zinc picolinate dihydrate added for nutritional purposes in food supplements / F. Aguilar; U.R. Charrondiere; B. Dusemund; P. Galtier; J. Gilbert; D.M. Gott; S. Grilli; R. Guertler; G.E.N. Kass; J. Koenig; C. Lambré; J-C. Larsen; J-C. Leblanc; A. Mortensen; D. Parent-Massin; I. Pratt; I.M.C.M. Rietjens; I. Stankovic; P. Tobback; T. Verguieva; R.A. Woutersen.. - In: EFSA JOURNAL. - ISSN 1831-4732. - ELETTRONICO. - 1113:(2009), pp. 1-41. [10.2903/j.efsa.2009.1113]
Chromium picolinate, zinc picolinate and zinc picolinate dihydrate added for nutritional purposes in food supplements
GRILLI, SANDRO;
2009
Abstract
The Panel also noted that, although the safety of zinc itself, in terms of amounts that may be consumed, is outside the remit of this Panel, at the 97.5th percentile the dietary zinc intake from total food only is already close to the UL, as established by the SCF. Based on the available, albeit limited toxicological database, the Panel concluded that at the anticipated use and use levels of zinc picolinate and zinc picolinate dihydrate, as a source of zinc, when added for nutritional purposes in food supplements, are not of safety concern as The Panel also concluded that the use of chromium (III) picolinate, as a source of chromium, is of no safety concern provided that the amount of supplemental chromium does not exceed the level of 250 μg/day, the value set by the World Health Organization. The Panel notes that recent reviews and evaluations of chromium (III) point at conflicting outcomes of genotoxicity assays and report diverging views and conclusions on the consequences of this genotoxicity issue for the ultimate safety assessment of chromium (III). The Panel is aware that given this situation, the safety of chromium (III) might need to be reevaluated in light of these recent reviews and evaluations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
