Human cytomegalovirus (HCMV) clinical isolates display genetic polymorphisms that are supposed to be implicated in HCMV-induced immunopathogenesis. Open reading frame UL73, encoding for the envelope glycoprotein N, shows four distinct genomic variants (gN-1, 2, 3, 4). This report analysed the distribution of glycoprotein N genotypes in 29 AIDS patients and 50 solid-organ transplant recipients compared with 111 immunocompetent individuals. HIV patients exhibited a prevalence of HCMV strains with the gN-1 genotype, which seem to replicate favourably in immunocompromised hosts.
Pignatelli S., Rossini G., Dal Monte P., Gatto M.R., Landini M.P. (2003). Human cytomegalovirus glycoprotein N genotypes in AIDS patients. AIDS, 17(5), 761-763 [10.1097/00002030-200303280-00018].
Human cytomegalovirus glycoprotein N genotypes in AIDS patients
Pignatelli S.;Dal Monte P.;Gatto M. R.;Landini M. P.
2003
Abstract
Human cytomegalovirus (HCMV) clinical isolates display genetic polymorphisms that are supposed to be implicated in HCMV-induced immunopathogenesis. Open reading frame UL73, encoding for the envelope glycoprotein N, shows four distinct genomic variants (gN-1, 2, 3, 4). This report analysed the distribution of glycoprotein N genotypes in 29 AIDS patients and 50 solid-organ transplant recipients compared with 111 immunocompetent individuals. HIV patients exhibited a prevalence of HCMV strains with the gN-1 genotype, which seem to replicate favourably in immunocompromised hosts.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
