Human cytomegalovirus (HCMV) clinical isolates display genetic polymorphisms that are supposed to be implicated in HCMV-induced immunopathogenesis. Open reading frame UL73, encoding for the envelope glycoprotein N, shows four distinct genomic variants (gN-1, 2, 3, 4). This report analysed the distribution of glycoprotein N genotypes in 29 AIDS patients and 50 solid-organ transplant recipients compared with 111 immunocompetent individuals. HIV patients exhibited a prevalence of HCMV strains with the gN-1 genotype, which seem to replicate favourably in immunocompromised hosts.

Pignatelli S., Rossini G., Dal Monte P., Gatto M.R., Landini M.P. (2003). Human cytomegalovirus glycoprotein N genotypes in AIDS patients. AIDS, 17(5), 761-763 [10.1097/00002030-200303280-00018].

Human cytomegalovirus glycoprotein N genotypes in AIDS patients

Pignatelli S.;Dal Monte P.;Gatto M. R.;Landini M. P.
2003

Abstract

Human cytomegalovirus (HCMV) clinical isolates display genetic polymorphisms that are supposed to be implicated in HCMV-induced immunopathogenesis. Open reading frame UL73, encoding for the envelope glycoprotein N, shows four distinct genomic variants (gN-1, 2, 3, 4). This report analysed the distribution of glycoprotein N genotypes in 29 AIDS patients and 50 solid-organ transplant recipients compared with 111 immunocompetent individuals. HIV patients exhibited a prevalence of HCMV strains with the gN-1 genotype, which seem to replicate favourably in immunocompromised hosts.
2003
Pignatelli S., Rossini G., Dal Monte P., Gatto M.R., Landini M.P. (2003). Human cytomegalovirus glycoprotein N genotypes in AIDS patients. AIDS, 17(5), 761-763 [10.1097/00002030-200303280-00018].
Pignatelli S.; Rossini G.; Dal Monte P.; Gatto M.R.; Landini M.P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/900772
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