Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.
Bonini B.F., Comes-Franchini M., Fochi M., Mazzanti G., Ricci A., Varchi G. (1998). A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides. SYNLETT, 1998(9), 1013-1015 [10.1055/s-1998-1831].
A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides
Bonini B. F.;Comes-Franchini M.;Fochi M.;Mazzanti G.;Ricci A.;Varchi G.
1998
Abstract
Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.File in questo prodotto:
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