Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.

A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides

Bonini B. F.;Comes-Franchini M.;Fochi M.;Mazzanti G.;Ricci A.;Varchi G.
1998

Abstract

Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.
1998
Bonini B.F.; Comes-Franchini M.; Fochi M.; Mazzanti G.; Ricci A.; Varchi G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/899377
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