Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.
A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides / Bonini B.F.; Comes-Franchini M.; Fochi M.; Mazzanti G.; Ricci A.; Varchi G.. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 1998:9(1998), pp. 1013-1015. [10.1055/s-1998-1831]
A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides
Bonini B. F.;Comes-Franchini M.;Fochi M.;Mazzanti G.;Ricci A.;Varchi G.
1998
Abstract
Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.