We have developed a new synthetic access to stereodefined diamino 1,2-diols starting from homochiral α-aminoacylsilanes. A [3+2] cycloaddition with benzo nitrile oxide of the vinylated adducts and a reductive ring opening constitute key steps of the reaction sequence.
Diastereoselective synthesis of diamino 1,2-diols from homochiral α-aminoacylsilanes / Bonini B.F.; Comes-Franchini M.; Fochi M.; Lunazzi L.; Mazzanti A.; Mazzanti G.; Ricci A.; Varchi G.. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 2001:SPEC. ISS(2001), pp. 995-998. [10.1055/s-2001-14644]
Diastereoselective synthesis of diamino 1,2-diols from homochiral α-aminoacylsilanes
Bonini B. F.;Comes-Franchini M.;Fochi M.;Lunazzi L.;Mazzanti A.;Mazzanti G.;Ricci A.;Varchi G.
2001
Abstract
We have developed a new synthetic access to stereodefined diamino 1,2-diols starting from homochiral α-aminoacylsilanes. A [3+2] cycloaddition with benzo nitrile oxide of the vinylated adducts and a reductive ring opening constitute key steps of the reaction sequence.File in questo prodotto:
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