We have developed a new synthetic access to stereodefined diamino 1,2-diols starting from homochiral α-aminoacylsilanes. A [3+2] cycloaddition with benzo nitrile oxide of the vinylated adducts and a reductive ring opening constitute key steps of the reaction sequence.
Bonini B.F., Comes-Franchini M., Fochi M., Lunazzi L., Mazzanti A., Mazzanti G., et al. (2001). Diastereoselective synthesis of diamino 1,2-diols from homochiral α-aminoacylsilanes. SYNLETT, 2001(SPEC. ISS), 995-998 [10.1055/s-2001-14644].
Diastereoselective synthesis of diamino 1,2-diols from homochiral α-aminoacylsilanes
Bonini B. F.;Comes-Franchini M.;Fochi M.;Lunazzi L.;Mazzanti A.;Mazzanti G.;Ricci A.;Varchi G.
2001
Abstract
We have developed a new synthetic access to stereodefined diamino 1,2-diols starting from homochiral α-aminoacylsilanes. A [3+2] cycloaddition with benzo nitrile oxide of the vinylated adducts and a reductive ring opening constitute key steps of the reaction sequence.File in questo prodotto:
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