We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical status and electroencephalographic recordings observed in this patient. We suggest that the interaction occurs at gastrointestinal level with a reduction of PHT and VPA oral bioavailability during antiviral treatment. © 1995 Raven press, Ltd., New york.
Possible interaction between acyclovir and antiepileptic treatment / Parmeggiani Antonia; Riva R.; Posar A.; Giovanardi Rossi Paola.. - In: THERAPEUTIC DRUG MONITORING. - ISSN 0163-4356. - STAMPA. - 17:3(1995), pp. 312-315. [10.1097/00007691-199506000-00017]
Possible interaction between acyclovir and antiepileptic treatment
Parmeggiani Antonia;Riva R.;Posar A.;Giovanardi Rossi Paola.
1995
Abstract
We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical status and electroencephalographic recordings observed in this patient. We suggest that the interaction occurs at gastrointestinal level with a reduction of PHT and VPA oral bioavailability during antiviral treatment. © 1995 Raven press, Ltd., New york.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
