We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical status and electroencephalographic recordings observed in this patient. We suggest that the interaction occurs at gastrointestinal level with a reduction of PHT and VPA oral bioavailability during antiviral treatment. © 1995 Raven press, Ltd., New york.

Parmeggiani Antonia, Riva R., Posar A., Giovanardi Rossi Paola. (1995). Possible interaction between acyclovir and antiepileptic treatment. THERAPEUTIC DRUG MONITORING, 17(3), 312-315 [10.1097/00007691-199506000-00017].

Possible interaction between acyclovir and antiepileptic treatment

Parmeggiani Antonia;Riva R.;Posar A.;Giovanardi Rossi Paola.
1995

Abstract

We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical status and electroencephalographic recordings observed in this patient. We suggest that the interaction occurs at gastrointestinal level with a reduction of PHT and VPA oral bioavailability during antiviral treatment. © 1995 Raven press, Ltd., New york.
1995
Parmeggiani Antonia, Riva R., Posar A., Giovanardi Rossi Paola. (1995). Possible interaction between acyclovir and antiepileptic treatment. THERAPEUTIC DRUG MONITORING, 17(3), 312-315 [10.1097/00007691-199506000-00017].
Parmeggiani Antonia; Riva R.; Posar A.; Giovanardi Rossi Paola.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/898698
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