The visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters is described. The photo-organocatalytic process, which occurs at ambient temperature and under visible light illumination, is triggered by the photochemical activity of in situ-generated electron donor-acceptor complexes, arising from the association of chiral enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.
Wozniak L., Murphy J.J., Melchiorre P. (2015). Photo-organocatalytic enantioselective perfluoroalkylation of β-ketoesters. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(17), 5678-5681 [10.1021/jacs.5b03243].
Photo-organocatalytic enantioselective perfluoroalkylation of β-ketoesters
Melchiorre P.
Ultimo
Supervision
2015
Abstract
The visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters is described. The photo-organocatalytic process, which occurs at ambient temperature and under visible light illumination, is triggered by the photochemical activity of in situ-generated electron donor-acceptor complexes, arising from the association of chiral enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
