Reported herein is a photochemical cascade process that combines the excited-state and ground-state reactivity of chiral organocatalytic intermediates. This strategy directly converts racemic cyclopropanols and α,β-unsaturated aldehydes into stereochemically dense cyclopentanols with exquisite stereoselectivity. Mechanistic investigations have enabled elucidating the origin of the stereoconvergence, which is governed by a kinetic resolution process.
Wozniak L., Magagnano G., Melchiorre P. (2018). Enantioselective Photochemical Organocascade Catalysis. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 57(4), 1068-1072 [10.1002/anie.201711397].
Enantioselective Photochemical Organocascade Catalysis
Melchiorre P.
Ultimo
Supervision
2018
Abstract
Reported herein is a photochemical cascade process that combines the excited-state and ground-state reactivity of chiral organocatalytic intermediates. This strategy directly converts racemic cyclopropanols and α,β-unsaturated aldehydes into stereochemically dense cyclopentanols with exquisite stereoselectivity. Mechanistic investigations have enabled elucidating the origin of the stereoconvergence, which is governed by a kinetic resolution process.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
