Background: We aimed to investigate the prescription pattern of pregabalin augmentation of antidepressants in major depressive disorder (MDD) and to explore variables associated with add-on pregabalin treatment. Methods: 1410 MDD patients participated in this naturalistic European multicenter study with retrospective assessment of treatment response. Analyses of covariance, chi-squared tests, and binary logistic regressions were accomplished to determine differences in socio-demographic and clinical characteristics between MDD patients with and without pregabalin augmentation. Results: Add-on pregabalin was established in 102 (7.23%) MDD patients. Compared to those without receiving pregabalin, pregabalin-treated patients were characterized by a significantly higher likelihood for older age (mean: 54.74 +/- 13.08 vs 49.93 +/- 14.13 years), unemployment (78.43% vs 51.23%), melancholic features (83.33% vs 58.94%), inpatient treatment (72.55% vs 31.65%), previous psychiatric hospitalizations (13.52 +/- 24.82 vs 4.96 +/- 19.93 weeks), any somatic comorbidity (68.63% vs 44.57%), comorbid hypertension (37.25% vs 17.51%), more severe depressive symptom severity at the onset of the current episode (mean MADRS: 37.55 +/- 9.00 vs 33.79 +/- 7.52), receiving augmentation/combination treatment strategies in general (mean number of psychotropic drugs: 3.64 +/- 0.92 vs 2.07 +/- 1.17), and with antidepressants (50.00% vs 27.91%) and antipsychotics (46.08% vs 24.08%) in particular. Limitations: Due to its observational cross-sectional study design, our patient sample might not be fully representative for MDD patients in primary care settings. Conclusions: Our findings suggest that add-on pregabalin is particularly administered in more severe/difficult-totreat MDD conditions, whereas no association between the prescription of adjunctive pregabalin and comorbid anxiety symptoms could be determined.

Dold, M., Bartova, L., Fugger, G., Mitschek, M.M., Fabbri, C., Serretti, A., et al. (2022). Pregabalin augmentation of antidepressants in major depression - results from a European multicenter study. JOURNAL OF AFFECTIVE DISORDERS, 296, 485-492 [10.1016/j.jad.2021.09.063].

Pregabalin augmentation of antidepressants in major depression - results from a European multicenter study

Fabbri, Chiara;Serretti, Alessandro;
2022

Abstract

Background: We aimed to investigate the prescription pattern of pregabalin augmentation of antidepressants in major depressive disorder (MDD) and to explore variables associated with add-on pregabalin treatment. Methods: 1410 MDD patients participated in this naturalistic European multicenter study with retrospective assessment of treatment response. Analyses of covariance, chi-squared tests, and binary logistic regressions were accomplished to determine differences in socio-demographic and clinical characteristics between MDD patients with and without pregabalin augmentation. Results: Add-on pregabalin was established in 102 (7.23%) MDD patients. Compared to those without receiving pregabalin, pregabalin-treated patients were characterized by a significantly higher likelihood for older age (mean: 54.74 +/- 13.08 vs 49.93 +/- 14.13 years), unemployment (78.43% vs 51.23%), melancholic features (83.33% vs 58.94%), inpatient treatment (72.55% vs 31.65%), previous psychiatric hospitalizations (13.52 +/- 24.82 vs 4.96 +/- 19.93 weeks), any somatic comorbidity (68.63% vs 44.57%), comorbid hypertension (37.25% vs 17.51%), more severe depressive symptom severity at the onset of the current episode (mean MADRS: 37.55 +/- 9.00 vs 33.79 +/- 7.52), receiving augmentation/combination treatment strategies in general (mean number of psychotropic drugs: 3.64 +/- 0.92 vs 2.07 +/- 1.17), and with antidepressants (50.00% vs 27.91%) and antipsychotics (46.08% vs 24.08%) in particular. Limitations: Due to its observational cross-sectional study design, our patient sample might not be fully representative for MDD patients in primary care settings. Conclusions: Our findings suggest that add-on pregabalin is particularly administered in more severe/difficult-totreat MDD conditions, whereas no association between the prescription of adjunctive pregabalin and comorbid anxiety symptoms could be determined.
2022
Dold, M., Bartova, L., Fugger, G., Mitschek, M.M., Fabbri, C., Serretti, A., et al. (2022). Pregabalin augmentation of antidepressants in major depression - results from a European multicenter study. JOURNAL OF AFFECTIVE DISORDERS, 296, 485-492 [10.1016/j.jad.2021.09.063].
Dold, Markus; Bartova, Lucie; Fugger, Gernot; Mitschek, Marleen Mm; Fabbri, Chiara; Serretti, Alessandro; Mendlewicz, Julien; Souery, Daniel; Zohar, J...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/897625
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