Tuberculosis (TB) caused by strains of Mycobacterium tuberculosis that are rifampicin-resistant (RR), multidrug-resistant (MDR) (strains resistant to at least isoniazid and rifampicin) or extensively drug-resistant (XDR) (MDR strains resistant to any fluoroquinolone (FQ) and to at least one second-line injectable drug (SLID): kanamycin, capreomycin or amikacin) is a major threat to TB control globally. All three groups require treatment with second-line drugs (SLDs). We previously reported that MDR- and XDR-TB in Italy occurred mostly in foreign-born persons (FBPs) , but no major information on RR, MDR or XDR trends in FBPs and Italian-born persons (IBPs) were shown. Here, we documented these trends from 2009 to 2016
Trend in rifampicin-, multidrug- and extensively drug-resistant tuberculosis in Italy, 2009-2016
Fattorini L.;Andreoni S.;Viggiani P.;De Lorenzo S.;Farina C.;Dal Monte P.;Fabio A.;Luciano E.;Sali M.;Sanguinetti M.;Gambi A.;Costa D.;Grimaldi A.;Giraldi C.;
2018
Abstract
Tuberculosis (TB) caused by strains of Mycobacterium tuberculosis that are rifampicin-resistant (RR), multidrug-resistant (MDR) (strains resistant to at least isoniazid and rifampicin) or extensively drug-resistant (XDR) (MDR strains resistant to any fluoroquinolone (FQ) and to at least one second-line injectable drug (SLID): kanamycin, capreomycin or amikacin) is a major threat to TB control globally. All three groups require treatment with second-line drugs (SLDs). We previously reported that MDR- and XDR-TB in Italy occurred mostly in foreign-born persons (FBPs) , but no major information on RR, MDR or XDR trends in FBPs and Italian-born persons (IBPs) were shown. Here, we documented these trends from 2009 to 2016I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.