Efficient methodologies based on consecutive radical ractions for the preparation of cyclonucleosides are reported. The reactions were performed on modified thymidine and 2'-deoxyadenosine substrates using (TMS)3SiH as the reducing agent. The rate constants for the 6-exo-trig radical cyclization have been estimated.
L. Navacchia, A. Manetto, P. C. Montevecchi, C. Chatgilialoglu (2005). Radical cyclization approach to cyclonucleosides. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 12, 4640-4648 [10.1002/ejoc.200500398].
Radical cyclization approach to cyclonucleosides
MONTEVECCHI, PIER CARLO;
2005
Abstract
Efficient methodologies based on consecutive radical ractions for the preparation of cyclonucleosides are reported. The reactions were performed on modified thymidine and 2'-deoxyadenosine substrates using (TMS)3SiH as the reducing agent. The rate constants for the 6-exo-trig radical cyclization have been estimated.File in questo prodotto:
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