Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.
Speziale P, Pietrocola G, Rindi S, Provenzano M, Provenza G, Di Poto A, et al. (2009). Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host. FUTURE MICROBIOLOGY, 4, 1337-1352 [10.2217/fmb.09.102].
Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host.
ARCIOLA, CARLA RENATA
2009
Abstract
Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
