Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.
Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host / Speziale P; Pietrocola G; Rindi S; Provenzano M; Provenza G; Di Poto A; Visai L; Arciola CR.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - STAMPA. - 4:(2009), pp. 1337-1352. [10.2217/fmb.09.102]
Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host.
ARCIOLA, CARLA RENATA
2009
Abstract
Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
