The diagnostic problems linked to human cytomegalovirus (HCMV) in pregnancy are many and not all have been fully defined. In long-term seropositive women there is a tacit agreement that no laboratory testing for HCMV should be carried out. In seronegative women a test for HCMV-specific IgG should be performed at least twice during the first 4 months of pregnancy, and if the seronegativity persists, further follow-up might be stopped. On the other hand, if a seropositivity appears the diagnosis of a primary HCMV infection is established and prenatal diagnosis should be offered to the mother. Finally, in the case of a pregnant woman with unknown serological status, the diagnosis of HCMV infection is a complex problem and several different questions need to be addressed. In our opinion they should be screened with a reliable IgM test (confirmed by blot if necessary) followed, in the case of positivity, by an avidity assay. Pregnant women undergoing a primary HCMV infection should be encouraged to seek prenatal diagnosis to be performed by PCR and virus isolation from amniotic fluid at the 21st to 23rd week of gestation.

Cytomegalovirus infection in pregnancy: A still complicated diagnostic problem / Lazzarotto T, Spezzacatena P, Pradelli P, Abate DA, Gabrielli L, Varani Stefania, Landini MP. - In: INTERVIROLOGY. - ISSN 0300-5526. - STAMPA. - 41:4-5(1998), pp. 149-157. [10.1159/000024929]

Cytomegalovirus infection in pregnancy: A still complicated diagnostic problem

Lazzarotto T;Varani Stefania;Landini MP
1998

Abstract

The diagnostic problems linked to human cytomegalovirus (HCMV) in pregnancy are many and not all have been fully defined. In long-term seropositive women there is a tacit agreement that no laboratory testing for HCMV should be carried out. In seronegative women a test for HCMV-specific IgG should be performed at least twice during the first 4 months of pregnancy, and if the seronegativity persists, further follow-up might be stopped. On the other hand, if a seropositivity appears the diagnosis of a primary HCMV infection is established and prenatal diagnosis should be offered to the mother. Finally, in the case of a pregnant woman with unknown serological status, the diagnosis of HCMV infection is a complex problem and several different questions need to be addressed. In our opinion they should be screened with a reliable IgM test (confirmed by blot if necessary) followed, in the case of positivity, by an avidity assay. Pregnant women undergoing a primary HCMV infection should be encouraged to seek prenatal diagnosis to be performed by PCR and virus isolation from amniotic fluid at the 21st to 23rd week of gestation.
1998
Cytomegalovirus infection in pregnancy: A still complicated diagnostic problem / Lazzarotto T, Spezzacatena P, Pradelli P, Abate DA, Gabrielli L, Varani Stefania, Landini MP. - In: INTERVIROLOGY. - ISSN 0300-5526. - STAMPA. - 41:4-5(1998), pp. 149-157. [10.1159/000024929]
Lazzarotto T, Spezzacatena P, Pradelli P, Abate DA, Gabrielli L, Varani Stefania, Landini MP
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/895644
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 5
social impact