To the Editor: Among the numerous clinical features of schizophrenia, the age at onset (AAO) is widely accepted as a significant clinical and prognostic factor (Ongür et al., 2009). AAO of schizophrenia is highly variable, ranging from mid adolescence to late adult life. An earlier onset may be due to a genetic propensity to develop illness, as those with an earlier onset are more likely to have relatives with schizophrenia (Byrne et al., 2002). Despite the large amount of data available, none of the thresholds of AAO used in clinical, biological and family studies have been validated. In this study we analyzed the AAO using the admixture analysis in order to assess the presence of different subgroups in a schizophrenia population.
Age at onset in Canadian schizophrenia patients: admixture analysis / Panariello, Fabio; O'Driscoll, Lauren; de Souza, Renan P; Tiwari, Arun; Manchia, Mirko; Kennedy, James; De Luca, Vincenzo. - In: SCHIZOPHRENIA RESEARCH. - ISSN 0920-9964. - STAMPA. - 122:278(2010), pp. 1-3. [10.1016/j.schres.2009.10.024]
Age at onset in Canadian schizophrenia patients: admixture analysis
Panariello, Fabio;
2010
Abstract
To the Editor: Among the numerous clinical features of schizophrenia, the age at onset (AAO) is widely accepted as a significant clinical and prognostic factor (Ongür et al., 2009). AAO of schizophrenia is highly variable, ranging from mid adolescence to late adult life. An earlier onset may be due to a genetic propensity to develop illness, as those with an earlier onset are more likely to have relatives with schizophrenia (Byrne et al., 2002). Despite the large amount of data available, none of the thresholds of AAO used in clinical, biological and family studies have been validated. In this study we analyzed the AAO using the admixture analysis in order to assess the presence of different subgroups in a schizophrenia population.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
