Symmetrically N,N′-substituted ureas were obtained from primary amines in very good yields under solvent-less conditions using diethyl carbonate (DEC) as the carbonylation reagent and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the base catalyst. The products are precipitated directly from the reaction mixture after a volatile organic compound (VOC) free aqueous work-up. The catalyst can be recovered and reused.
Ballini, R., Fiorini, D., Maggi, R., Righi, P., Sartori, G., Sartorio, R. (2003). TBD-catalysed solventless synthesis of symmetrically N,N′-substituted ureas from primary amines and diethyl carbonate. GREEN CHEMISTRY, 5(4), 396-398 [10.1039/B301951A].
TBD-catalysed solventless synthesis of symmetrically N,N′-substituted ureas from primary amines and diethyl carbonate
Righi, Paolo
;
2003
Abstract
Symmetrically N,N′-substituted ureas were obtained from primary amines in very good yields under solvent-less conditions using diethyl carbonate (DEC) as the carbonylation reagent and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the base catalyst. The products are precipitated directly from the reaction mixture after a volatile organic compound (VOC) free aqueous work-up. The catalyst can be recovered and reused.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
