(equation presented) Elusive nitroacetic acid esters and amides were obtained through a halogen exchange reaction of the corresponding bromoacetic acid derivatives with polymer-supported nitrite anion. The process is flawed by a side product catalyzed degradation of the products. Domino processes turned out to be a powerful tool for overcoming such drawbacks, converting a substandard reaction into an efficient multicomponent preparation of 4-hydroxy-4,5-dihydroisoxazoles.
Scardovi N., Casalini A., Peri F., Righi P. (2002). Domino processes as a tool for recovering substandard reactions. Synthesis and use of nitroacetic acid esters and amides. ORGANIC LETTERS, 4(6), 965-968 [10.1021/ol0255357].
Domino processes as a tool for recovering substandard reactions. Synthesis and use of nitroacetic acid esters and amides
Scardovi N.;Peri F.;Righi P.
2002
Abstract
(equation presented) Elusive nitroacetic acid esters and amides were obtained through a halogen exchange reaction of the corresponding bromoacetic acid derivatives with polymer-supported nitrite anion. The process is flawed by a side product catalyzed degradation of the products. Domino processes turned out to be a powerful tool for overcoming such drawbacks, converting a substandard reaction into an efficient multicomponent preparation of 4-hydroxy-4,5-dihydroisoxazoles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
