(equation presented) Elusive nitroacetic acid esters and amides were obtained through a halogen exchange reaction of the corresponding bromoacetic acid derivatives with polymer-supported nitrite anion. The process is flawed by a side product catalyzed degradation of the products. Domino processes turned out to be a powerful tool for overcoming such drawbacks, converting a substandard reaction into an efficient multicomponent preparation of 4-hydroxy-4,5-dihydroisoxazoles.
Domino processes as a tool for recovering substandard reactions. Synthesis and use of nitroacetic acid esters and amides / Scardovi N.; Casalini A.; Peri F.; Righi P.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 4:6(2002), pp. 965-968. [10.1021/ol0255357]
Domino processes as a tool for recovering substandard reactions. Synthesis and use of nitroacetic acid esters and amides
Scardovi N.;Peri F.;Righi P.
2002
Abstract
(equation presented) Elusive nitroacetic acid esters and amides were obtained through a halogen exchange reaction of the corresponding bromoacetic acid derivatives with polymer-supported nitrite anion. The process is flawed by a side product catalyzed degradation of the products. Domino processes turned out to be a powerful tool for overcoming such drawbacks, converting a substandard reaction into an efficient multicomponent preparation of 4-hydroxy-4,5-dihydroisoxazoles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
