A variety of 2-alkylidene-1,4-diols have been conveniently prepared, in two steps, by conjugate addition of a nitroalkane to the appropriate enedione derivatives under basic conditions (DBU), followed by chemoselective reduction (LiAlH4/Et2O) of the carbonyl functionalities of the Michael adduct, obtained after elimination of nitrous acid.
Ballini R., Bosica G., Damiani M., Righi P. (1999). Nitroalkanes as a new source of 2-alkylidene-1,4-diols, in two steps. TETRAHEDRON, 55(47), 13451-13456 [10.1016/S0040-4020(99)00829-7].
Nitroalkanes as a new source of 2-alkylidene-1,4-diols, in two steps
Righi P.
1999
Abstract
A variety of 2-alkylidene-1,4-diols have been conveniently prepared, in two steps, by conjugate addition of a nitroalkane to the appropriate enedione derivatives under basic conditions (DBU), followed by chemoselective reduction (LiAlH4/Et2O) of the carbonyl functionalities of the Michael adduct, obtained after elimination of nitrous acid.File in questo prodotto:
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