Background: Diabetes Mellitus (DM) may occur in IBD and influence the disease progression. Aim: To compare disease course and treatment outcomes in IBD patients with and without DM. Methods: This is a systematic review with meta-analysis comparing patients with IBD plus DM with patients with IBD only. Primary endpoints: need for surgery, IBD-related complications, hospitalizations, sepsis, mortality. Quality of life and costs were assessed. Results: Five studies with 71,216 patients (49.1% with DM) were included. Risk for IBD-related complica- tions (OR = 1.12, I 2 98% p = 0.77), mortality (OR = 1.52, I 2 98% p = 0.37) and IBD-related surgery (OR = 1.20, I 2 81% p = 0.26) did not differ. Risk of IBD-related hospitalizations (OR = 2.52, I 2 0% p < 0.0 0 0 01) and sep- sis (OR = 1.56, I 2 88% p = 0.0 0 03) was higher in the IBD + DM group. Risk of pneumonia and urinary tract infections was higher in the IBD + DM group (OR = 1.72 and OR = 1.93), while risk of C. Difficile infection did not differ (OR = 1.22 I 2 88% p = 0.37). Mean Short Inflammatory Bowel Disease Questionnaire score was lower in the IBD + DM group (38.9 vs. 47, p = 0.03). Mean health care costs per year were $10,598.2 vs $3747.3 ( p < 0.001). Conclusion: DM might negatively affect the course of IBD by increasing the risk of hospitalization and infections, but not IBD-related complications and mortality.
Influence of diabetes mellitus on inflammatory bowel disease course and treatment outcomes. A systematic review with meta-analysis / Fuschillo, Giacomo; Celentano, Valerio; Rottoli, Matteo; Sciaudone, Guido; Gravina, Antonietta Gerarda; Pellegrino, Raffaele; Marfella, Raffaele; Romano, Marco; Selvaggi, Francesco; Pellino, Gianluca. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - ELETTRONICO. - epub ahed of print:(2022), pp. 1-7. [10.1016/j.dld.2022.08.017]
Influence of diabetes mellitus on inflammatory bowel disease course and treatment outcomes. A systematic review with meta-analysis
Rottoli, Matteo;
2022
Abstract
Background: Diabetes Mellitus (DM) may occur in IBD and influence the disease progression. Aim: To compare disease course and treatment outcomes in IBD patients with and without DM. Methods: This is a systematic review with meta-analysis comparing patients with IBD plus DM with patients with IBD only. Primary endpoints: need for surgery, IBD-related complications, hospitalizations, sepsis, mortality. Quality of life and costs were assessed. Results: Five studies with 71,216 patients (49.1% with DM) were included. Risk for IBD-related complica- tions (OR = 1.12, I 2 98% p = 0.77), mortality (OR = 1.52, I 2 98% p = 0.37) and IBD-related surgery (OR = 1.20, I 2 81% p = 0.26) did not differ. Risk of IBD-related hospitalizations (OR = 2.52, I 2 0% p < 0.0 0 0 01) and sep- sis (OR = 1.56, I 2 88% p = 0.0 0 03) was higher in the IBD + DM group. Risk of pneumonia and urinary tract infections was higher in the IBD + DM group (OR = 1.72 and OR = 1.93), while risk of C. Difficile infection did not differ (OR = 1.22 I 2 88% p = 0.37). Mean Short Inflammatory Bowel Disease Questionnaire score was lower in the IBD + DM group (38.9 vs. 47, p = 0.03). Mean health care costs per year were $10,598.2 vs $3747.3 ( p < 0.001). Conclusion: DM might negatively affect the course of IBD by increasing the risk of hospitalization and infections, but not IBD-related complications and mortality.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
