In recent years, several studies investigated the complex process called "reprogramming" of seminoma (S) cells. The accepted pathogenetic model is a complex network including SOX2, SOX17, OCT3/4 and PRAME, which modulates the epigenetic transcription of numerous downstream genes and drives a divergent gene expression profile resulting in the transition from pure S (P-S) to S component (S-C) of mixed germ cell tumors of the testis (M-GCTT), and finally to embryonal carcinoma (EC). Herein, we tested a large cohort of GCTT with SOX2 and PRAME to evaluate their expression in the evolutionary steps of GCTT and verify if the modulation in the expression of these two molecules could be relevant for the fate of GCTT.

SOX2 and PRAME in the "reprogramming" of seminoma cells / Orsatti, Agnese; Sirolli, Maria; Ambrosi, Francesca; Franceschini, Tania; Giunchi, Francesca; Franchini, Eugenia; Grillini, Marco; Massari, Francesco; Mollica, Veronica; Bianchi, Federico Mineo; Colecchia, Maurizio; Fiorentino, Michelangelo; Ricci, Costantino. - In: PATHOLOGY, RESEARCH AND PRACTICE. - ISSN 1618-0631. - ELETTRONICO. - 238:(2022), pp. 154044.237-154044.237. [10.1016/j.prp.2022.154044]

SOX2 and PRAME in the "reprogramming" of seminoma cells

Orsatti, Agnese;Sirolli, Maria;Ambrosi, Francesca;Franceschini, Tania;Giunchi, Francesca;Franchini, Eugenia;Grillini, Marco;Massari, Francesco;Mollica, Veronica;Bianchi, Federico Mineo;Fiorentino, Michelangelo;Ricci, Costantino
2022

Abstract

In recent years, several studies investigated the complex process called "reprogramming" of seminoma (S) cells. The accepted pathogenetic model is a complex network including SOX2, SOX17, OCT3/4 and PRAME, which modulates the epigenetic transcription of numerous downstream genes and drives a divergent gene expression profile resulting in the transition from pure S (P-S) to S component (S-C) of mixed germ cell tumors of the testis (M-GCTT), and finally to embryonal carcinoma (EC). Herein, we tested a large cohort of GCTT with SOX2 and PRAME to evaluate their expression in the evolutionary steps of GCTT and verify if the modulation in the expression of these two molecules could be relevant for the fate of GCTT.
2022
SOX2 and PRAME in the "reprogramming" of seminoma cells / Orsatti, Agnese; Sirolli, Maria; Ambrosi, Francesca; Franceschini, Tania; Giunchi, Francesca; Franchini, Eugenia; Grillini, Marco; Massari, Francesco; Mollica, Veronica; Bianchi, Federico Mineo; Colecchia, Maurizio; Fiorentino, Michelangelo; Ricci, Costantino. - In: PATHOLOGY, RESEARCH AND PRACTICE. - ISSN 1618-0631. - ELETTRONICO. - 238:(2022), pp. 154044.237-154044.237. [10.1016/j.prp.2022.154044]
Orsatti, Agnese; Sirolli, Maria; Ambrosi, Francesca; Franceschini, Tania; Giunchi, Francesca; Franchini, Eugenia; Grillini, Marco; Massari, Francesco; Mollica, Veronica; Bianchi, Federico Mineo; Colecchia, Maurizio; Fiorentino, Michelangelo; Ricci, Costantino
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/892868
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