RANTES (regulated upon activation, normal T-cell expressed and secreted), a CC chemokine, appears to play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RR-MS), enhancing the inflammatory response within the nervous system. We have demonstrated that RANTES production is increased in RR-MS compared to controls. Interferon-β-1b (IFN-β-1b) treatment reduces RANTES production in sera and peripheral blood adherent mononuclear cell (PBAM) supernatants both in relapse and remission. IFN-β-1b also reduces RANTES expression in PBAM. Our results suggest that RANTES modulation might represent one of the mechanisms of action of IFN-β-1b in RR-MS. Copyright (C) 2000 Elsevier Science B.V.
Iarlori C., Reale M., Lugaresi A., De Luca G., Bonanni L., Di Iorio A., et al. (2000). RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with interferon-β-1b. JOURNAL OF NEUROIMMUNOLOGY, 107(1), 100-107 [10.1016/S0165-5728(00)00261-7].
RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with interferon-β-1b
Lugaresi A.Writing – Review & Editing
;
2000
Abstract
RANTES (regulated upon activation, normal T-cell expressed and secreted), a CC chemokine, appears to play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RR-MS), enhancing the inflammatory response within the nervous system. We have demonstrated that RANTES production is increased in RR-MS compared to controls. Interferon-β-1b (IFN-β-1b) treatment reduces RANTES production in sera and peripheral blood adherent mononuclear cell (PBAM) supernatants both in relapse and remission. IFN-β-1b also reduces RANTES expression in PBAM. Our results suggest that RANTES modulation might represent one of the mechanisms of action of IFN-β-1b in RR-MS. Copyright (C) 2000 Elsevier Science B.V.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
