We demonstrated that ConA-induced suppressor cell function is decreased in dysiimune polyneuropathies (D-PNP) during relapses or progression. Plasma exchange (PE) and prednisone are effective in D-PNP. In this study we investigated suppressor cell function in 11 idiopathic CIDP (8 men and 3 women; age 48.4±21.5, range 11-75 yrs) and in 5 paraproteinemic neuropathies with antisulfated glucuronyl paragloboside antibodies (anti-SGPG) (all men; age 63.4±9.2, range 4973) before and after treatment(at 2 weeks for PE, 3 pts; at 3-6 months for prednisone, 13 pts). After treatment suppressor cell function significantly increased in both groups (CIDP=21±4.1 vs 40.18±5.01, p=0.0001; anti-SGPG=15.6±4.2 vs 39.6±5.07, p= 0.0002). In 1 CIDP patient a relapse during treatment tapering, was associated with decreased suppressor activity. In dysimmune neuropathies suppressor cell function correlates inversely with disease activity and shows a favourable response to treatment.
De Luca G., Lugaresi A., Larlori C., Marzoli F., Di Guglielmo G., Uncini A., et al. (1997). Plasma exchange and prednisone improve suppressor cell function in dysimmune neuropathies. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 18(4), 34-34.
Plasma exchange and prednisone improve suppressor cell function in dysimmune neuropathies
Lugaresi A.Secondo
Methodology
;
1997
Abstract
We demonstrated that ConA-induced suppressor cell function is decreased in dysiimune polyneuropathies (D-PNP) during relapses or progression. Plasma exchange (PE) and prednisone are effective in D-PNP. In this study we investigated suppressor cell function in 11 idiopathic CIDP (8 men and 3 women; age 48.4±21.5, range 11-75 yrs) and in 5 paraproteinemic neuropathies with antisulfated glucuronyl paragloboside antibodies (anti-SGPG) (all men; age 63.4±9.2, range 4973) before and after treatment(at 2 weeks for PE, 3 pts; at 3-6 months for prednisone, 13 pts). After treatment suppressor cell function significantly increased in both groups (CIDP=21±4.1 vs 40.18±5.01, p=0.0001; anti-SGPG=15.6±4.2 vs 39.6±5.07, p= 0.0002). In 1 CIDP patient a relapse during treatment tapering, was associated with decreased suppressor activity. In dysimmune neuropathies suppressor cell function correlates inversely with disease activity and shows a favourable response to treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
