We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon β, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon β might represent an adjunctive therapy in CIDP both acting on a defective blood- nerve barrier and normalizing an otherwise defective suppressor cell function.
De Luca G., Lugaresi A., Iarlori C., Marzoli F., Uncini A., Gambi D. (1998). Interferon beta normalizes suppressor cell function in dysimmune neuropathies. JOURNAL OF NEUROIMMUNOLOGY, 82(1), 1-4 [10.1016/S0165-5728(97)00170-7].
Interferon beta normalizes suppressor cell function in dysimmune neuropathies
Lugaresi A.Secondo
Conceptualization
;
1998
Abstract
We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon β, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon β might represent an adjunctive therapy in CIDP both acting on a defective blood- nerve barrier and normalizing an otherwise defective suppressor cell function.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
