Patients with end-stage renal disease are 10 to 20 times more at risk of cardiovascular death than the general population. Traditional cardiovascular risk factors are not able to explain the increase in the onset of cardiovascular diseases in dialysis patients. Some of the most important non traditional risk factors in uremic patients are: the inflammatory state of the patients, cytokines and growth factors, hyperhomocysteinemia, the presence of alterations of the calcium phosphorous product which can already be in progress when the glomerular filtration rate decreases to less than 60 mL/min. Clinically, these alterations cause vascular calcifications, calcifications of the heart valves and calcific uremic arteriolopathy or calciphylaxis. The pathogenesis of vascular calcification is complex and cannot be assigned to a simple, passive process: in fact, it includes factors which promote or inhibit calcification. In turn, these pathologic conditions have been found to be highly predictive of general and cardiovascular death. Given the serious clinical consequences that vascular calcifications can cause, it is necessary to carry out an early mapping of the traditional and non traditional risk factors of uremic patients as it seems that therapeutic interventions aimed at reducing or inverting the calcification process can improve the outcome of patients, above all when they are started quickly.

The cardiovascular burden of end-stage renal disease patients / Cianciolo, G; Donati, G; La Manna, G; Ferri, A; Cuna, V; Ubaldi, G; Corsini, S; Lanci, N; Colì L; Stefoni, S.. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - STAMPA. - 62(1):(2010), pp. 51-66.

The cardiovascular burden of end-stage renal disease patients.

CIANCIOLO, GIUSEPPE;DONATI, GABRIELE;LA MANNA, GAETANO;FERRI, ANNAMARIA;CUNA, VANIA;UBALDI, GIULIA;CORSINI, SERENA;LANCI, NICOLE;COLI', LUIGI;STEFONI, SERGIO
2010

Abstract

Patients with end-stage renal disease are 10 to 20 times more at risk of cardiovascular death than the general population. Traditional cardiovascular risk factors are not able to explain the increase in the onset of cardiovascular diseases in dialysis patients. Some of the most important non traditional risk factors in uremic patients are: the inflammatory state of the patients, cytokines and growth factors, hyperhomocysteinemia, the presence of alterations of the calcium phosphorous product which can already be in progress when the glomerular filtration rate decreases to less than 60 mL/min. Clinically, these alterations cause vascular calcifications, calcifications of the heart valves and calcific uremic arteriolopathy or calciphylaxis. The pathogenesis of vascular calcification is complex and cannot be assigned to a simple, passive process: in fact, it includes factors which promote or inhibit calcification. In turn, these pathologic conditions have been found to be highly predictive of general and cardiovascular death. Given the serious clinical consequences that vascular calcifications can cause, it is necessary to carry out an early mapping of the traditional and non traditional risk factors of uremic patients as it seems that therapeutic interventions aimed at reducing or inverting the calcification process can improve the outcome of patients, above all when they are started quickly.
2010
The cardiovascular burden of end-stage renal disease patients / Cianciolo, G; Donati, G; La Manna, G; Ferri, A; Cuna, V; Ubaldi, G; Corsini, S; Lanci, N; Colì L; Stefoni, S.. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - STAMPA. - 62(1):(2010), pp. 51-66.
Cianciolo, G; Donati, G; La Manna, G; Ferri, A; Cuna, V; Ubaldi, G; Corsini, S; Lanci, N; Colì L; Stefoni, S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/89048
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