Benign mammary lesions are infrequent in cats. Among these, the most common is feline fibroadenomatous change, a hyperplastic/dysplastic change associated with hormonal imbalances. Although never thoroughly described in scientific literature, feline fibroadenomas, which share some morphological features with fibroadenomatous change, have been variably included in classification systems. The aim of this study was to characterise feline mammary fibroadenomas from a histological and immunophenotypical point of view in order to allow the standardisation of classification. Nine cases were retrospectively collected from eight female and one male cat with no history of hormonal stimulation. Diagnostic inclusion criteria were defined and immunohistochemistry was performed. Histologically, nodules were composed of neoplastic epithelial cells arranged in arborizing lobularlike structures surrounded by abundant proliferating stroma. In all analysed cases, epithelial elements showed immunolabelling for pancytokeratin, cytokeratin19, and -catenin. Interestingly, five cases showed multifocal epithelial vimentin positivity. Epithelial nuclear oestrogen receptor positivity was observed in three of the nine samples. In all cases, myoepithelial cells did not extend into the interstitium. Stromal cells expressed vimentin, calponin, and mild -catenin. The median Ki67 scores were 18% and 8.3% in the epithelial and stromal components, respectively. This study describes, for the first time, the morphological and immunophenotypical features of feline mammary fibroadenoma, highlighting its existence as a separate entity from fibroadenomatous change.

Mammary Fibroadenoma in Cats: A Matter of Classification / Filippo Torrigiani, Valentina Moccia, Barbara Brunetti, Francesca Millanta, Guillermo Valdivia, Laura Peña, Laura Cavicchioli and Valentina Zappulli. - In: VETERINARY SCIENCES. - ISSN 2306-7381. - ELETTRONICO. - 9:(2022), pp. 253.1-253.12. [10.3390/vetsci9060253]

Mammary Fibroadenoma in Cats: A Matter of Classification

Barbara Brunetti;
2022

Abstract

Benign mammary lesions are infrequent in cats. Among these, the most common is feline fibroadenomatous change, a hyperplastic/dysplastic change associated with hormonal imbalances. Although never thoroughly described in scientific literature, feline fibroadenomas, which share some morphological features with fibroadenomatous change, have been variably included in classification systems. The aim of this study was to characterise feline mammary fibroadenomas from a histological and immunophenotypical point of view in order to allow the standardisation of classification. Nine cases were retrospectively collected from eight female and one male cat with no history of hormonal stimulation. Diagnostic inclusion criteria were defined and immunohistochemistry was performed. Histologically, nodules were composed of neoplastic epithelial cells arranged in arborizing lobularlike structures surrounded by abundant proliferating stroma. In all analysed cases, epithelial elements showed immunolabelling for pancytokeratin, cytokeratin19, and -catenin. Interestingly, five cases showed multifocal epithelial vimentin positivity. Epithelial nuclear oestrogen receptor positivity was observed in three of the nine samples. In all cases, myoepithelial cells did not extend into the interstitium. Stromal cells expressed vimentin, calponin, and mild -catenin. The median Ki67 scores were 18% and 8.3% in the epithelial and stromal components, respectively. This study describes, for the first time, the morphological and immunophenotypical features of feline mammary fibroadenoma, highlighting its existence as a separate entity from fibroadenomatous change.
2022
Mammary Fibroadenoma in Cats: A Matter of Classification / Filippo Torrigiani, Valentina Moccia, Barbara Brunetti, Francesca Millanta, Guillermo Valdivia, Laura Peña, Laura Cavicchioli and Valentina Zappulli. - In: VETERINARY SCIENCES. - ISSN 2306-7381. - ELETTRONICO. - 9:(2022), pp. 253.1-253.12. [10.3390/vetsci9060253]
Filippo Torrigiani, Valentina Moccia, Barbara Brunetti, Francesca Millanta, Guillermo Valdivia, Laura Peña, Laura Cavicchioli and Valentina Zappulli
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/889956
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