A series of 4-diazoimidazole-5-carboxamides bearing in position 2 lipophilic substituents was synthesized and their antimicrobial activity was evaluated in vitro against pathogenic Gram-positive, Gram-negative bacteria and fungi. Some compounds presented antifungal activity, particularly two derivatives (1g and 1h) showed good MIC values (10-50 μg/ml) against both moulds and yeasts. © 2001 Elsevier Science S.A. All rights reserved.
Synthesis and antimicrobial activity of new diazoimidazole derivatives containing an N-acylpyrrolidine ring
Varoli L.;Burnelli S.;Garuti L.;Vitali B.
2001
Abstract
A series of 4-diazoimidazole-5-carboxamides bearing in position 2 lipophilic substituents was synthesized and their antimicrobial activity was evaluated in vitro against pathogenic Gram-positive, Gram-negative bacteria and fungi. Some compounds presented antifungal activity, particularly two derivatives (1g and 1h) showed good MIC values (10-50 μg/ml) against both moulds and yeasts. © 2001 Elsevier Science S.A. All rights reserved.File in questo prodotto:
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