In a clinical trial, 10 patients suffering from irritable bowel syndrome or functional diarrhea were administered the probiotic preparation VSL-3. Preliminary results indicated that administration of VSL-3 improved the clinical picture and changed the composition and biochemistry of fecal microbiota. Titer variations of intestinal bacterial groups were evaluated by culture and PCR techniques. A significant increase in lactobacilli, bifidobacteria and Streptococcus thermophilus was observed as a consequence of probiotic treatment, while enterococci, coliforms, Bacteroides and Clostridium perfringens did not change significantly. The strains Bifidobacterium infantis Y1 and Bifidobacterium breve Y8, included in VSL-3, were specifically detected in feces of patients treated with the probiotic by using strain-specific PCR primers. In addition, fecal β-galactosidase increased and urease activities decreased as a result of changes in the intestinal microbiota induced by VSL-3 administration. © 2001 Éditions scientifiques et médicales Elsevier SAS.

Brigidi P., Vitali B., Swennen E., Bazzocchi G., Matteuzzi D. (2001). Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. RESEARCH IN MICROBIOLOGY, 152(8), 735-741 [10.1016/S0923-2508(01)01254-2].

Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea

Brigidi P.;Vitali B.;Swennen E.;Bazzocchi G.;Matteuzzi D.
2001

Abstract

In a clinical trial, 10 patients suffering from irritable bowel syndrome or functional diarrhea were administered the probiotic preparation VSL-3. Preliminary results indicated that administration of VSL-3 improved the clinical picture and changed the composition and biochemistry of fecal microbiota. Titer variations of intestinal bacterial groups were evaluated by culture and PCR techniques. A significant increase in lactobacilli, bifidobacteria and Streptococcus thermophilus was observed as a consequence of probiotic treatment, while enterococci, coliforms, Bacteroides and Clostridium perfringens did not change significantly. The strains Bifidobacterium infantis Y1 and Bifidobacterium breve Y8, included in VSL-3, were specifically detected in feces of patients treated with the probiotic by using strain-specific PCR primers. In addition, fecal β-galactosidase increased and urease activities decreased as a result of changes in the intestinal microbiota induced by VSL-3 administration. © 2001 Éditions scientifiques et médicales Elsevier SAS.
2001
Brigidi P., Vitali B., Swennen E., Bazzocchi G., Matteuzzi D. (2001). Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. RESEARCH IN MICROBIOLOGY, 152(8), 735-741 [10.1016/S0923-2508(01)01254-2].
Brigidi P.; Vitali B.; Swennen E.; Bazzocchi G.; Matteuzzi D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/887217
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