In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

Keratin-hydrotalcites hybrid films for drug delivery applications

Giuri D.;Sagnella A.;Ferroni C.;Sotgiu G.;Varchi G.;
2018

Abstract

In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.
Posati T.; Giuri D.; Nocchetti M.; Sagnella A.; Gariboldi M.; Ferroni C.; Sotgiu G.; Varchi G.; Zamboni R.; Aluigi A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/879967
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