Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone) (PCL-TES) loaded with bioactive glasses (BG) are here presented. Unloaded PCL-TES, as well as PCL/BG nanocomposite fibers, are also considered for comparison. It is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of the polymer and the silanol groups at the BG particle surface, thus generating additional crosslinking points with respect to those present in the PCL-TES system. The as-spun PCL-TES/BG fibers display excellent shape memory properties, in terms of shape fixity and shape recovery ratios, without the need of a thermal crosslinking treatment. BG particles confer in vitro bioactivity to PCL-based nanocomposite fibers and favor the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests demonstrate that the addition of BG particles to PCL-based polymer does not inhibit ST-2 cell viability. This novel approach of using bioactive glasses not only for their biological properties, but also for the enhancement of shape memory properties of PCL-based polymers, widens the versatility and suitability of the obtained composite fibers for a huge portfolio of biomedical applications.

Liverani, L., Liguori, A., Zezza, P., Gualandi, C., Toselli, M., Boccaccini, A.R., et al. (2022). Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties. BIOACTIVE MATERIALS, 11, 230-239 [10.1016/j.bioactmat.2021.09.020].

Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties

Liguori, Anna;Zezza, Paola;Gualandi, Chiara;Toselli, Maurizio;Focarete, Maria Letizia
2022

Abstract

Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone) (PCL-TES) loaded with bioactive glasses (BG) are here presented. Unloaded PCL-TES, as well as PCL/BG nanocomposite fibers, are also considered for comparison. It is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of the polymer and the silanol groups at the BG particle surface, thus generating additional crosslinking points with respect to those present in the PCL-TES system. The as-spun PCL-TES/BG fibers display excellent shape memory properties, in terms of shape fixity and shape recovery ratios, without the need of a thermal crosslinking treatment. BG particles confer in vitro bioactivity to PCL-based nanocomposite fibers and favor the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests demonstrate that the addition of BG particles to PCL-based polymer does not inhibit ST-2 cell viability. This novel approach of using bioactive glasses not only for their biological properties, but also for the enhancement of shape memory properties of PCL-based polymers, widens the versatility and suitability of the obtained composite fibers for a huge portfolio of biomedical applications.
2022
Liverani, L., Liguori, A., Zezza, P., Gualandi, C., Toselli, M., Boccaccini, A.R., et al. (2022). Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties. BIOACTIVE MATERIALS, 11, 230-239 [10.1016/j.bioactmat.2021.09.020].
Liverani, Liliana; Liguori, Anna; Zezza, Paola; Gualandi, Chiara; Toselli, Maurizio; Boccaccini, Aldo R.; Focarete, Maria Letizia
File in questo prodotto:
File Dimensione Formato  
2022 Bioactive Materials vol11 pp230239.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
Dimensione 8.26 MB
Formato Adobe PDF
8.26 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/879121
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 22
social impact