N,N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing, approach to N,N-disubstituted homoallylamines and β-aminoesters.
Bernardi L., Bonini B.F., Capito E., Dessole G., Fochi M., Comes-Franchini M., et al. (2003). A New and Practical Procedure for the Bruylants Reaction. Zinc-Mediated Synthesis of Tertiary Homoallylamines and β-Aminoesters. SYNLETT, 2003(12), 1778-1782 [10.1055/s-2003-41471].
A New and Practical Procedure for the Bruylants Reaction. Zinc-Mediated Synthesis of Tertiary Homoallylamines and β-Aminoesters
Bernardi L.;Bonini B. F.;Dessole G.;Fochi M.;Comes-Franchini M.;Ricci A.
2003
Abstract
N,N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing, approach to N,N-disubstituted homoallylamines and β-aminoesters.File in questo prodotto:
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