N,N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing, approach to N,N-disubstituted homoallylamines and β-aminoesters.
A New and Practical Procedure for the Bruylants Reaction. Zinc-Mediated Synthesis of Tertiary Homoallylamines and β-Aminoesters / Bernardi L.; Bonini B.F.; Capito E.; Dessole G.; Fochi M.; Comes-Franchini M.; Ricci A.. - In: SYNLETT. - ISSN 0936-5214. - ELETTRONICO. - 2003:12(2003), pp. 1778-1782. [10.1055/s-2003-41471]
A New and Practical Procedure for the Bruylants Reaction. Zinc-Mediated Synthesis of Tertiary Homoallylamines and β-Aminoesters
Bernardi L.;Bonini B. F.;Dessole G.;Fochi M.;Comes-Franchini M.;Ricci A.
2003
Abstract
N,N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing, approach to N,N-disubstituted homoallylamines and β-aminoesters.File in questo prodotto:
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