Enantiomerically pure β-hydroxyalkyl and β-aminoalkyl ferrocenyl sulfides have been synthesized in good yields from mercaptoferrocene and amino alcohol derivatives. Primary β-aminoalkyl sulfides allowed the synthesis of tetrahydro-1,4-thiazepines containing the ferrocene moiety with good diastereoselectivity and β-iminoalkyl sulfides. Some of these derivatives have successfully been employed as ligands for palladium-catalyzed allylic substitution, with asymmetric induction of up to 99% ee. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).
Bernardi L., Bonini B.F., Comes-Franchini M., Fochi M., Mazzanti G., Ricci A., et al. (2002). Synthesis and reactivities of enantiomerically pure β hydroxyalkyl and β-aminoalkyl ferrocenyl sulfides. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2002(16), 2776-2784 [10.1002/1099-0690(200208)2002:16<2776::AID-EJOC2776>3.0.CO;2-Y].
Synthesis and reactivities of enantiomerically pure β hydroxyalkyl and β-aminoalkyl ferrocenyl sulfides
Bernardi L.;Bonini B. F.;Comes-Franchini M.;Fochi M.;Mazzanti G.;Ricci A.;Varchi G.
2002
Abstract
Enantiomerically pure β-hydroxyalkyl and β-aminoalkyl ferrocenyl sulfides have been synthesized in good yields from mercaptoferrocene and amino alcohol derivatives. Primary β-aminoalkyl sulfides allowed the synthesis of tetrahydro-1,4-thiazepines containing the ferrocene moiety with good diastereoselectivity and β-iminoalkyl sulfides. Some of these derivatives have successfully been employed as ligands for palladium-catalyzed allylic substitution, with asymmetric induction of up to 99% ee. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
