Aim: To determine the systemic uptake of 5-aminosalicylic acid (5-ASA) and acetyl-5-ASA (Ac-5-ASA) at steady state during treatment with either an azo-bond preparation, olsalazine, or a delayed-release mesalazine. Methods: In an open cross-over trial with randomized sequence, 15 patients with ulcerative colitis in remission were given 7-day courses of olsalazine (Dipentum 1.0 g daily) and of mesalazine (Asacol 1.6 g daily). Plasma and urine were collected on days 6 and 7 of each course and concentrations of 5-ASA and Ac-5-ASA were determined by high-performance liquid chromatography (HPLC). Results: Mean steady-state plasma concentrations of 5-ASA and Ac-5-ASA were significantly higher after treatment with mesalazine than with olsalazine (P < 0.0001). Total urinary excretion of 5-ASA and Ac-5-ASA as a percentage of the given dose was significantly higher on mesalazine than on olsalazine (P < 0.01). Only two patients experienced, during the first 3 days of treatment with olsalazine, transient watery diarrhoea which resolved spontaneously. No unexpected or major changes in haematology or biochemistry were detected during the study. Conclusion: As 5-ASA acts locally, the lower systemic load provided by olsalazine may increase efficacy and reduce the potential risk of nephrotoxicity during long-term maintenance treatment of ulcerative colitis.

Gionchetti P., Campieri M., Venturi A., Rizzello F., Ferretti M., Brignola C., et al. (1996). Systemic availability of 5-aminosalicylic acid: Comparison of delayed release and an azo-bond preparation. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 10(4), 601-605 [10.1046/j.1365-2036.1996.26168000.x].

Systemic availability of 5-aminosalicylic acid: Comparison of delayed release and an azo-bond preparation

Gionchetti P.;Campieri M.;Rizzello F.;Brignola C.;Miglioli M.
1996

Abstract

Aim: To determine the systemic uptake of 5-aminosalicylic acid (5-ASA) and acetyl-5-ASA (Ac-5-ASA) at steady state during treatment with either an azo-bond preparation, olsalazine, or a delayed-release mesalazine. Methods: In an open cross-over trial with randomized sequence, 15 patients with ulcerative colitis in remission were given 7-day courses of olsalazine (Dipentum 1.0 g daily) and of mesalazine (Asacol 1.6 g daily). Plasma and urine were collected on days 6 and 7 of each course and concentrations of 5-ASA and Ac-5-ASA were determined by high-performance liquid chromatography (HPLC). Results: Mean steady-state plasma concentrations of 5-ASA and Ac-5-ASA were significantly higher after treatment with mesalazine than with olsalazine (P < 0.0001). Total urinary excretion of 5-ASA and Ac-5-ASA as a percentage of the given dose was significantly higher on mesalazine than on olsalazine (P < 0.01). Only two patients experienced, during the first 3 days of treatment with olsalazine, transient watery diarrhoea which resolved spontaneously. No unexpected or major changes in haematology or biochemistry were detected during the study. Conclusion: As 5-ASA acts locally, the lower systemic load provided by olsalazine may increase efficacy and reduce the potential risk of nephrotoxicity during long-term maintenance treatment of ulcerative colitis.
1996
Gionchetti P., Campieri M., Venturi A., Rizzello F., Ferretti M., Brignola C., et al. (1996). Systemic availability of 5-aminosalicylic acid: Comparison of delayed release and an azo-bond preparation. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 10(4), 601-605 [10.1046/j.1365-2036.1996.26168000.x].
Gionchetti P.; Campieri M.; Venturi A.; Rizzello F.; Ferretti M.; Brignola C.; Miglioli M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/876529
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